# Diffuse Weakness
***Acute/Subacute/Chronic diffuse weakness, most likely due to ***. No evidence of localizing weakness and neuro exam is unremarkable. Dx includes weakness secondary to infection, electrolyte/metabolic disturbance, neuromuscular insult, inflammatory disorders, endocrinopathy, drugs and toxins.
- If true muscle weakness, pain, or localized, consider imaging, ESR, CRP, CK
- TSH, B12, A1c, RPR
- CXR, UA/UCx, BCx x 2
- BMP, CBC