# Systemic lupus erythematosus (SLE) flare
Patient with known history of SLE who presents with *** concerning for lupus flare, given change in symptomatology and lab findings.
- CBC with diff, smear, BCx x2, CMP, ESR, CRP, Anti-dsDNA, C3, C4
- No indication to repeat ANA if positive
- CXR, UA with microscopy, Urine P/Cr,
- Additional organ specific labs/imaging per clinical scenario
- Appreciate rheumatology consult